The biological basis of human sexual orientation: is there a role for epigenetic
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« on: December 04, 2014, 01:04:17 am »

The biological basis of human sexual orientation: is there a role for epigenetics?
Ngun TC, Vilain E.
Advances in Genetics 2014
http://www.ncbi.nlm.nih.gov/pubmed/25172350

Sexual orientation is one of the largest sex differences in humans. The vast majority of the population is heterosexual, that is, they are attracted to members of the opposite sex. However, a small but significant proportion of people are bisexual or homosexual and experience attraction to members of the same sex. The origins of the phenomenon have long been the subject of scientific study. In this chapter, we will review the evidence that sexual orientation has biological underpinnings and consider the involvement of epigenetic mechanisms. We will first discuss studies that show that sexual orientation has a genetic component. These studies show that sexual orientation is more concordant in monozygotic twins than in dizygotic ones and that male sexual orientation is linked to several regions of the genome. We will then highlight findings that suggest a link between sexual orientation and epigenetic mechanisms. In particular, we will consider the case of women with congenital adrenal hyperplasia (CAH). These women were exposed to high levels of testosterone in utero and have much higher rates of nonheterosexual orientation compared to non-CAH women. Studies in animal models strongly suggest that the long-term effects of hormonal exposure (such as those experienced by CAH women) are mediated by epigenetic mechanisms. We conclude by describing a hypothetical framework that unifies genetic and epigenetic explanations of sexual orientation and the continued challenges facing sexual orientation research.
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« Reply #1 on: January 01, 2018, 02:48:27 am »

So, you're convinced it is largely due to hormone-levels?  Roll Eyes
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« Reply #2 on: January 01, 2018, 05:18:29 am »

So, you're convinced it is largely due to hormone-levels?  Roll Eyes

Since the 1990s most of the mainstream researchers talk about the 'homosexualties' rather than 'homosexuality'.  There seem to be many pathways to identifying as gay/lesbian and hormone exposure during pregnancy seems to be one of the possibilities.

It certainly works that way for cows.
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« Reply #3 on: January 01, 2018, 03:21:23 pm »

it his another nature v nurture debate...it will always be a confluence of a lot of factors
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« Reply #4 on: January 02, 2018, 12:03:37 am »

There are some factors that are more important than others.  I kind of worry about WHY people study the origin of homosexuality.

Some gay people study it in the hope that if they can show it is 'biological' then people will accept that it is 'normal'.  Despite the history of discriminating against people for inherited differences like skin colour, hair texture, and gender.

My second year genetics professor at University stated that he hoped they could find a 'gay gene' so that homosexuals could be diagnosed in utero and aborted.  I'm glad that the 'gay gene' has been disproven.
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« Reply #5 on: January 05, 2018, 07:31:23 am »

So, you're convinced it is largely due to hormone-levels?  Roll Eyes

Since the 1990s most of the mainstream researchers talk about the 'homosexualties' rather than 'homosexuality'.  There seem to be many pathways to identifying as gay/lesbian and hormone exposure during pregnancy seems to be one of the possibilities.

It certainly works that way for cows.

So, you are taking 1 possibility as the only one & even suggesting that is completely why some bulls are attracted to other bulls? REALLY? Roll Eyes
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« Reply #6 on: January 05, 2018, 11:58:05 pm »

Are you incapable of recognizing the plural in English.  ie Homosexualities or many or pathways or 'one of the possibilities'?

AS to Freemartins (female cows who have male twins NOT bulls)
https://en.wikipedia.org/wiki/Freemartin
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